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Issue 74, 2015
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Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

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Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

Graphical abstract: Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

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Article information


Submitted
22 Jun 2015
Accepted
03 Aug 2015
First published
03 Aug 2015

This article is Open Access

Chem. Commun., 2015,51, 14099-14102
Article type
Communication
Author version available

Reversible DNA i-motif to hairpin switching induced by copper(II) cations

H. A. Day, E. P. Wright, C. J. MacDonald, A. J. Gates and Z. A. E. Waller, Chem. Commun., 2015, 51, 14099 DOI: 10.1039/C5CC05111H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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