Issue 67, 2015
From the journal:

Chemical Communications

The copper-catalyzed synthesis of β-trifluoromethylated acrylonitriles and trifluoromethyl-substituted 2H-azirines†

Yu-Tao He,a   Qiang Wang,a   Jiahui Zhao,a   Xue-Yuan Liu,a   Peng-Fei Xua  and  Yong-Min Liang*ab  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China
E-mail: liangym@lzu.edu.cn
Fax: +86 931-891-2582

b State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou, P. R. China

Abstract

The direct assembly of acrylonitriles and valuable 2H-azirines from readily available starting materials is described. This novel alkyne difunctionalization reaction proceeded under mild reaction conditions. Considering the versatile roles of 2H-azirines, this work paves the way for further modification into various heterocycles.

Graphical abstract: The copper-catalyzed synthesis of β-trifluoromethylated acrylonitriles and trifluoromethyl-substituted 2H-azirines

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Article information

DOI
https://doi.org/10.1039/C5CC05066A
Article type
Communication
Submitted
19 Jun 2015
Accepted
09 Jul 2015
First published
10 Jul 2015

Chem. Commun., 2015,51, 13209-13212

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The copper-catalyzed synthesis of β-trifluoromethylated acrylonitriles and trifluoromethyl-substituted 2H-azirines

Y. He, Q. Wang, J. Zhao, X. Liu, P. Xu and Y. Liang, Chem. Commun., 2015, 51, 13209 DOI: 10.1039/C5CC05066A

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