Issue 61, 2015
From the journal:

Chemical Communications

Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli†

Xiang Chen,ab   Zhi-Qiang Liu,ab   Jian-Feng Huang,ab   Chao-Ping Linab  and  Yu-Guo Zheng*ab  

* Corresponding authors

a Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
E-mail: zhengyg@zjut.edu.cn
Fax: +86-571-88320630
Tel: +86-571-88320630

b Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

Three short-chain alcohol dehydrogenases from Burkholderia gladioli were discovered for their great potential in the dynamic kinetic asymmetric transformation of methyl 2-benzamido-methyl-3-oxobutanoate, and their screening against varied organic solvents and substrates. This is the first report of recombinant enzymes capable of achieving this reaction with the highest enantio- and diastereo-selectivity.

Graphical abstract: Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli

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Article information

DOI
https://doi.org/10.1039/C5CC04652A
Article type
Communication
Submitted
05 Jun 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

Chem. Commun., 2015,51, 12328-12331

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Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli

X. Chen, Z. Liu, J. Huang, C. Lin and Y. Zheng, Chem. Commun., 2015, 51, 12328 DOI: 10.1039/C5CC04652A

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