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Issue 62, 2015
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[18F]–NHC–BF3 adducts as water stable radio-prosthetic groups for PET imaging

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Abstract

The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [18F]–positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an 18F–19F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.

Graphical abstract: [18F]–NHC–BF3 adducts as water stable radio-prosthetic groups for PET imaging

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Publication details

The article was received on 03 Jun 2015, accepted on 25 Jun 2015 and first published on 26 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC04545B
Chem. Commun., 2015,51, 12439-12442

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    [18F]–NHC–BF3 adducts as water stable radio-prosthetic groups for PET imaging

    K. Chansaenpak, M. Wang, Z. Wu, R. Zaman, Z. Li and F. P. Gabbaï, Chem. Commun., 2015, 51, 12439
    DOI: 10.1039/C5CC04545B

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