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Issue 60, 2015
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Gene delivery polymer structure–function relationships elucidated via principal component analysis

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Abstract

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

Graphical abstract: Gene delivery polymer structure–function relationships elucidated via principal component analysis

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Article information


Submitted
29 May 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

Chem. Commun., 2015,51, 12134-12137
Article type
Communication
Author version available

Gene delivery polymer structure–function relationships elucidated via principal component analysis

C. J. Bishop, B. Abubaker-Sharif, T. Guiriba, S. Y. Tzeng and J. J. Green, Chem. Commun., 2015, 51, 12134
DOI: 10.1039/C5CC04417K

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