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Issue 58, 2015
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Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

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Abstract

A nanohybrid is assembled by ratiometrically co-loading Pt(IV) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.

Graphical abstract: Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

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Publication details

The article was received on 28 May 2015, accepted on 11 Jun 2015 and first published on 12 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC04376J
Chem. Commun., 2015,51, 11587-11590

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    Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

    Z. Wang, R. Ma, L. Yan, X. Chen and G. Zhu, Chem. Commun., 2015, 51, 11587
    DOI: 10.1039/C5CC04376J

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