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Issue 58, 2015
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A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes

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Abstract

A novel method of enantioselective 1,3-dioxane construction via a hemiacetalization/intramolecular oxy-Michael addition cascade by a chiral phosphoric acid catalyst was developed. The product was successfully transformed into an optically active 1,3-polyol motif, indicating that the proposed reaction can provide useful chiral building blocks for the de novo synthesis of polyketides.

Graphical abstract: A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes

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Article information


Submitted
19 May 2015
Accepted
09 Jun 2015
First published
12 Jun 2015

Chem. Commun., 2015,51, 11693-11696
Article type
Communication

A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes

A. Matsumoto, K. Asano and S. Matsubara, Chem. Commun., 2015, 51, 11693
DOI: 10.1039/C5CC04124D

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