Metal-free synthesis of N-fused heterocyclic iodides via C–H functionalization mediated by tert-butylhydroperoxide†
Abstract
Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported. This regioselective C–H functionalization is mediated by tert-butylhydroperoxide (TBHP), via dual activation of molecular iodine and a heterocyclic substrate, resulting in the in situ generation of electrophilic iodine species (I+), and free radical(s) tBuO˙ or tBuOO˙, driving the iodination reaction.