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Issue 64, 2015
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Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

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Abstract

A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.

Graphical abstract: Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

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Supplementary files

Article information


Submitted
07 May 2015
Accepted
06 Jul 2015
First published
06 Jul 2015

Chem. Commun., 2015,51, 12787-12790
Article type
Communication
Author version available

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

J. Bae, L. E. McNamara, M. A. Nael, F. Mahdi, R. J. Doerksen, G. L. Bidwell, N. I. Hammer and S. Jo, Chem. Commun., 2015, 51, 12787
DOI: 10.1039/C5CC03824C

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