Issue 64, 2015
From the journal:

Chemical Communications

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue†

Jungeun Bae,a   Louis E. McNamara,b   Manal A. Nael,c   Fakhri Mahdi,d   Robert J. Doerksen,c   Gene L. Bidwell, III,d   Nathan I. Hammerb  and  Seongbong Jo*a  

* Corresponding authors

a Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
E-mail: seongjo@olemiss.edu

b Department of Chemistry and Biochemistry, The University of Mississippi, University, MS 38677, USA

c Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA

d Department of Neurology, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA

Abstract

A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.

Graphical abstract: Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

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Article information

DOI
https://doi.org/10.1039/C5CC03824C
Article type
Communication
Submitted
07 May 2015
Accepted
06 Jul 2015
First published
06 Jul 2015

Chem. Commun., 2015,51, 12787-12790

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Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

J. Bae, L. E. McNamara, M. A. Nael, F. Mahdi, R. J. Doerksen, G. L. Bidwell, N. I. Hammer and S. Jo, Chem. Commun., 2015, 51, 12787 DOI: 10.1039/C5CC03824C

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