Issue 66, 2015
From the journal:

Chemical Communications

Highly-efficient T4 DNA ligase-based SNP analysis using a ligation fragment containing a modified nucleobase at the end†

Eui Kyoung Jang,a   Munhee Yangb  and  Seung Pil Pack*a  

* Corresponding authors

a Department of Biotechnology and Bioinformatics, Korea University, Jochiwon, Korea
E-mail: spack@korea.ac.kr
Fax: +82-44-860-1598
Tel: +82-44-860-1419

b Department of Psychology, University of Texas, Austin, USA

Abstract

A highly accurate ligase-based SNP analysis was developed by using modified base-end downstream ligation fragments as detection probes, which can clearly distinguish C/T SNP types without any “false-positive” results.

Graphical abstract: Highly-efficient T4 DNA ligase-based SNP analysis using a ligation fragment containing a modified nucleobase at the end

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Article information

DOI
https://doi.org/10.1039/C5CC03761A
Article type
Communication
Submitted
06 May 2015
Accepted
06 Jul 2015
First published
06 Jul 2015

Chem. Commun., 2015,51, 13090-13093

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Highly-efficient T4 DNA ligase-based SNP analysis using a ligation fragment containing a modified nucleobase at the end

E. K. Jang, M. Yang and S. P. Pack, Chem. Commun., 2015, 51, 13090 DOI: 10.1039/C5CC03761A

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