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Issue 51, 2015
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Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms

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Abstract

Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a D-galactosyl-β1–3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2–3-sialyltransferase or an α2–6-sialyltransferase.

Graphical abstract: Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms

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Supplementary files

Article information


Submitted
05 May 2015
Accepted
20 May 2015
First published
20 May 2015

Chem. Commun., 2015,51, 10310-10313
Article type
Communication
Author version available

Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms

L. Li, Y. Liu, T. Li, W. Wang, Z. Yu, C. Ma, J. Qu, W. Zhao, X. Chen and P. G. Wang, Chem. Commun., 2015, 51, 10310
DOI: 10.1039/C5CC03746H

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