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Issue 53, 2015
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Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

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Abstract

Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody–drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.

Graphical abstract: Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

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Supplementary files

Article information


Submitted
28 Apr 2015
Accepted
29 May 2015
First published
01 Jun 2015

This article is Open Access

Chem. Commun., 2015,51, 10624-10627
Article type
Communication

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

J. P. M. Nunes, M. Morais, V. Vassileva, E. Robinson, V. S. Rajkumar, M. E. B. Smith, R. B. Pedley, S. Caddick, J. R. Baker and V. Chudasama, Chem. Commun., 2015, 51, 10624
DOI: 10.1039/C5CC03557K

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