Issue 56, 2015
From the journal:

Chemical Communications

A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage†

Jonathan D. Freedman,‡ab   Hrvoje Lusic,‡c   Martin Wiewiorski,b   Michelle Farley,de   Brian D. Snyderb  and  Mark W. Grinstaff*acf  

* Corresponding authors

a Department of Pharmacology at Boston University, Boston University School of Medicine, Boston, MA, USA
E-mail: mgrin@bu.edu

b Center for Advanced Orthopaedic Studies, Harvard Medical School, Boston, MA, USA

c Department of Chemistry, Boston University, Boston, MA, USA

d MRI Core Facility, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA, USA

e MIT Institute for Medical Engineering & Science, Cambridge, MA, USA

f Biomedical Engineering, Boston University, Boston, MA, USA

Abstract

A new cationic gadolinium contrast agent is reported for delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The agent partitions into the glycosaminoglycan rich matrix of articular cartilage, based on Donnan equilibrium theory, and its use enables imaging of the human cadaveric metacarpal phalangeal joint.

Graphical abstract: A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage

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Article information

DOI
https://doi.org/10.1039/C5CC03354C
Article type
Communication
Submitted
23 Apr 2015
Accepted
29 May 2015
First published
29 May 2015

Chem. Commun., 2015,51, 11166-11169

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A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage

J. D. Freedman, H. Lusic, M. Wiewiorski, M. Farley, B. D. Snyder and M. W. Grinstaff, Chem. Commun., 2015, 51, 11166 DOI: 10.1039/C5CC03354C

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