Issue 57, 2015
From the journal:

Chemical Communications

Heck–Mizoroki coupling of vinyliodide and applications in the synthesis of dienes and trienes†

Katrina S. Madden,a   Sylvain David,a   Jonathan P. Knowlesb  and  Andrew Whiting*a  

* Corresponding authors

a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: andy.whiting@durham.ac.uk

b Department of Chemistry, University of Bristol, Cantock's Close, Bristol, UK

Abstract

Vinyliodide reacts chemoselectively under Heck–Mizoroki conditions with terminal alkenes, including vinylboronate esters, to give dienes. The resulting dienylboronates undergo Suzuki–Miyaura couplings with aryl, heteroaryl and alkenyl halides to access dienes and trienes.

Graphical abstract: Heck–Mizoroki coupling of vinyliodide and applications in the synthesis of dienes and trienes

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Article information

DOI
https://doi.org/10.1039/C5CC03273C
Article type
Communication
Submitted
20 Apr 2015
Accepted
10 Jun 2015
First published
11 Jun 2015

Chem. Commun., 2015,51, 11409-11412

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Heck–Mizoroki coupling of vinyliodide and applications in the synthesis of dienes and trienes

K. S. Madden, S. David, J. P. Knowles and A. Whiting, Chem. Commun., 2015, 51, 11409 DOI: 10.1039/C5CC03273C

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