Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted 19F MR signal

Shigetaka Nakamura; Kenzo Fujimoto

doi:10.1039/C5CC02972D

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Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted ¹⁹F MR signal†

Shigetaka Nakamura^a and Kenzo Fujimoto*^ab

Author affiliations

* Corresponding authors

^a Materials Science and Technology, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa, Japan
E-mail: kenzo@jaist.ac.jp

^b Research Center for Bio-Architecture, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa, Japan

Abstract

Photo-cross-linking of trifluorothymidine (^TFT) using 3-cyanovinylcarbazole (^CNVK) clearly shifted its ¹⁹F nuclear magnetic resonance (NMR) signal 8 ppm. This ^CNVK mediated ultrafast photo-cross-linking-induced shift can be utilized for miRNA detection by hybridization chain reaction (HCR) to detect 10 nM of a target in a sequence-specific manner.

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Article information

DOI: https://doi.org/10.1039/C5CC02972D
Article type: Communication
Submitted: 10 Apr 2015
Accepted: 29 Apr 2015
First published: 29 Apr 2015

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Chem. Commun., 2015,51, 11765-11768

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Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted ¹⁹F MR signal

S. Nakamura and K. Fujimoto, Chem. Commun., 2015, 51, 11765 DOI: 10.1039/C5CC02972D

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Chemical Communications