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Issue 59, 2015
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Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted 19F MR signal

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Abstract

Photo-cross-linking of trifluorothymidine (TFT) using 3-cyanovinylcarbazole (CNVK) clearly shifted its 19F nuclear magnetic resonance (NMR) signal 8 ppm. This CNVK mediated ultrafast photo-cross-linking-induced shift can be utilized for miRNA detection by hybridization chain reaction (HCR) to detect 10 nM of a target in a sequence-specific manner.

Graphical abstract: Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted 19F MR signal

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Supplementary files

Article information


Submitted
10 Apr 2015
Accepted
29 Apr 2015
First published
29 Apr 2015

Chem. Commun., 2015,51, 11765-11768
Article type
Communication

Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted 19F MR signal

S. Nakamura and K. Fujimoto, Chem. Commun., 2015, 51, 11765
DOI: 10.1039/C5CC02972D

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