Issue 43, 2015
From the journal:

Chemical Communications

An in situ Raman spectroscopy-based microfluidic “lab-on-a-chip” platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms†

Jinsong Feng,a   César de la Fuente-Núñez,b   Michael J. Trimble,b   Jie Xu,c   Robert E. W. Hancockb  and  Xiaonan Lu*a  

* Corresponding authors

a Food, Nutrition, and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada
E-mail: xiaonan.lu@ubc.ca
Tel: 604-822-2551

b Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada

c Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, Illinois, USA

Abstract

Pseudomonas aeruginosa biofilm was cultivated and characterized in a microfluidic “lab-on-a-chip” platform coupled with confocal Raman microscopy in a non-destructive manner. Biofilm formation could be quantified by this label-free platform and correlated well with confocal laser scanning microscopy. This Raman-microfluidic platform could also discriminate biofilms at different developmental stages.

Graphical abstract: An in situ Raman spectroscopy-based microfluidic “lab-on-a-chip” platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms

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Article information

DOI
https://doi.org/10.1039/C5CC02744F
Article type
Communication
Submitted
02 Apr 2015
Accepted
22 Apr 2015
First published
22 Apr 2015

Chem. Commun., 2015,51, 8966-8969

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An in situ Raman spectroscopy-based microfluidic “lab-on-a-chip” platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms

J. Feng, C. de la Fuente-Núñez, M. J. Trimble, J. Xu, R. E. W. Hancock and X. Lu, Chem. Commun., 2015, 51, 8966 DOI: 10.1039/C5CC02744F

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