Issue 50, 2015
From the journal:

Chemical Communications

Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”†

Zengchao Tang,a   Dan Li,*a   Yafei Luan,a   Lijuan Zhu,a   Hui Du,a   Yunwen Tao,c   Yanwei Wang,a   David M. Haddletonb  and  Hong Chen*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Rd, Suzhou 215123, Jiangsu, P. R. China
E-mail: chenh@suda.edu.cn, lidan@suda.edu.cn
Tel: +86-512-65880827

b Department of Chemistry, University of Warwick, Coventry, CV47AL, UK

c Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, Texas 75275-0314, USA

Abstract

A hexapeptide derived from an enzyme inhibitor was used as an affinity ligand for the conjugation of a hydrophilic polymer to the enzyme. The peptide targeted the polymer to the “berth” of the inhibitor in the enzyme, affording the enzyme resistance to the inhibitor without affecting the enzymatic activity.

Graphical abstract: Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”

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Article information

DOI
https://doi.org/10.1039/C5CC02659H
Article type
Communication
Submitted
31 Mar 2015
Accepted
28 Apr 2015
First published
28 Apr 2015

Chem. Commun., 2015,51, 10099-10102

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Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”

Z. Tang, D. Li, Y. Luan, L. Zhu, H. Du, Y. Tao, Y. Wang, D. M. Haddleton and H. Chen, Chem. Commun., 2015, 51, 10099 DOI: 10.1039/C5CC02659H

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