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Issue 45, 2015
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The development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells

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Abstract

A low-toxicity nucleus staining fluorescent probe, CDb12, was developed for real time mitosis imaging in live cells. CDb12 was identified by unbiased high-throughput imaging-based screening of a new xanthone library (AX). Unlike the conventional Hoechst dye, the low toxicity of CDb12 allows long term monitoring of cell division over more than one cell cycle.

Graphical abstract: The development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells

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Supplementary files

Article information


Submitted
19 Mar 2015
Accepted
20 Apr 2015
First published
24 Apr 2015

Chem. Commun., 2015,51, 9336-9338
Article type
Communication
Author version available

The development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells

K. K. Ghosh, Y. Jeong, N. Kang, J. Lee, W. Si Yan Diana, J. Kim, J. Yoo, D. Kim, Y. K. Kim and Y. Chang, Chem. Commun., 2015, 51, 9336
DOI: 10.1039/C5CC02295A

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