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Issue 55, 2015
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Design and synthesis of active heparan sulfate-based probes

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Abstract

A chemoenzymatic approach for synthesizing heparan sulfate oligosaccharides with a reactive diazoacetyl saccharide residue is reported. The resultant oligosaccharides were demonstrated to serve as specific inhibitors for heparan sulfate sulfotransferases, offering a new set of tools to probe the structural selectivity for heparan sulfate-binding proteins.

Graphical abstract: Design and synthesis of active heparan sulfate-based probes

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Supplementary files

Article information


Submitted
09 Mar 2015
Accepted
09 Jun 2015
First published
09 Jun 2015

Chem. Commun., 2015,51, 11019-11021
Article type
Communication
Author version available

Design and synthesis of active heparan sulfate-based probes

W. Zhou, P. Hsieh, Y. Xu, T. R. O’Leary, X. Huang and J. Liu, Chem. Commun., 2015, 51, 11019
DOI: 10.1039/C5CC02008E

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