Issue 35, 2015
From the journal:

Chemical Communications

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients†

Edward J. Howe,a   Babatunde O. Okesolaa  and  David K. Smith*a  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
E-mail: david.smith@york.ac.uk

Abstract

A simple supramolecular hydrogel based on 1,3:2,4-di(4-acylhydrazide)benzylidene sorbitol (DBS-CONHNH2), is able to extract acid-functionalised anti-inflammatory drugs via directed interactions with the self-assembled gel nanofibres. Two-component hydrogel-drug hybrid materials can be easily formed by mixing and exhibit pH-controlled drug release.

Graphical abstract: Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

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Article information

DOI
https://doi.org/10.1039/C5CC01868D
Article type
Communication
Submitted
04 Mar 2015
Accepted
19 Mar 2015
First published
31 Mar 2015

Chem. Commun., 2015,51, 7451-7454

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Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

E. J. Howe, B. O. Okesola and D. K. Smith, Chem. Commun., 2015, 51, 7451 DOI: 10.1039/C5CC01868D

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