Issue 34, 2015
From the journal:

Chemical Communications

Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach†

Liyun Zhang,‡*ab   Jun Cheng Er,‡c   Xin Li,a   Jun Jie Heng,d   Animesh Samanta,e   Young-Tae Changbe  and  Chi-Lik Ken Lee*d  

* Corresponding authors

a Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China
E-mail: zly0605@ustc.edu.cn

b Department of Chemistry, National University of Singapore, 3 Science Drive 2, Singapore

c Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences, #05-01, 28 Medical Drive, 117456 Singapore

d Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore
E-mail: KenLee@sp.edu.sg
Fax: +86-551-63607335
Tel: +86-551-63603125

e Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore

Abstract

A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity.

Graphical abstract: Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach

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Article information

DOI
https://doi.org/10.1039/C5CC01601K
Article type
Communication
Submitted
23 Feb 2015
Accepted
23 Mar 2015
First published
24 Mar 2015

Chem. Commun., 2015,51, 7386-7389

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Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach

L. Zhang, J. C. Er, X. Li, J. J. Heng, A. Samanta, Y. Chang and C. K. Lee, Chem. Commun., 2015, 51, 7386 DOI: 10.1039/C5CC01601K

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