The first nickel-catalyzed thiolation of unactivated C(sp3)–H bonds with disulfides was described. This transformation uses (dppp)NiCl2 as a catalyst and BINOL as a ligand, which are efficient for the thiolation of β-methyl C(sp3)–H bonds of a broad range of aliphatic carboxamides. The reaction provides an efficient synthetic pathway to access diverse thioethers.
S. Yan, Y. Liu, B. Liu, Y. Liu, Z. Zhang and B. Shi, Chem. Commun., 2015, 51, 7341 DOI: 10.1039/C5CC01436K
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