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Issue 62, 2015
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α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

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Abstract

The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

Graphical abstract: α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

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Article information


Submitted
15 Feb 2015
Accepted
18 Jun 2015
First published
29 Jun 2015

Chem. Commun., 2015,51, 12349-12352
Article type
Communication

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

A. Lampel, E. Elis, T. Guterman, S. Shapira, P. Marco, E. Bacharach and E. Gazit, Chem. Commun., 2015, 51, 12349
DOI: 10.1039/C5CC01421B

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