Issue 62, 2015
From the journal:

Chemical Communications

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments†

Ayala Lampel,a   Efrat Elis,b   Tom Guterman,a   Sharon Shapira,a   Pini Marco,c   Eran Bacharachb  and  Ehud Gazit*ad  

* Corresponding authors

a Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

b Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

c Department of Molecular Biology & Ecology of Plants, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

d Department of Materials Science and Engineering, Iby & Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel

Abstract

The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

Graphical abstract: α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC01421B
Article type
Communication
Submitted
15 Feb 2015
Accepted
18 Jun 2015
First published
29 Jun 2015

Chem. Commun., 2015,51, 12349-12352

Permissions

Request permissions

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

A. Lampel, E. Elis, T. Guterman, S. Shapira, P. Marco, E. Bacharach and E. Gazit, Chem. Commun., 2015, 51, 12349 DOI: 10.1039/C5CC01421B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements