Issue 50, 2015
From the journal:

Chemical Communications

Stereoselective synthesis of epoxyisoprostanes: an organocatalytic and “pot-economy” approach†

Jiang Weng,‡*a   Sheng Wang,‡a   Lin-Jie Huang,a   Zhang-Yi Luoa  and  Gui Lu*ab  

* Corresponding authors

a Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China
E-mail: wengj2@mail.sysu.edu.cn, lugui@mail.sysu.edu.cn
Fax: +86-20-3994-3048

b Institute of Human Virology, Sun Yat-sen University, Guangzhou 510080, People's Republic of China

Abstract

An efficient and direct synthetic route to epoxyisoprostane EC methyl ester has been accomplished in 8 steps (10% overall yield) from readily available starting materials using a series of asymmetric organocatalytic reactions and one-pot operations.

Graphical abstract: Stereoselective synthesis of epoxyisoprostanes: an organocatalytic and “pot-economy” approach

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Article information

DOI
https://doi.org/10.1039/C5CC01077B
Article type
Communication
Submitted
05 Feb 2015
Accepted
11 May 2015
First published
11 May 2015

Chem. Commun., 2015,51, 10170-10173

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Stereoselective synthesis of epoxyisoprostanes: an organocatalytic and “pot-economy” approach

J. Weng, S. Wang, L. Huang, Z. Luo and G. Lu, Chem. Commun., 2015, 51, 10170 DOI: 10.1039/C5CC01077B

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