Issue 32, 2015
From the journal:

Chemical Communications

Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery†

Nithya Subramanian,‡ab   Jagat R. Kanwar,*b   Balachandran Akilandeswari,bd   Rupinder K. Kanwar,b   Vikas Khetanc  and  Subramanian Krishnakumar*ad  

* Corresponding authors

a Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, India
E-mail: drkrishnakumar_2000@yahoo.com

b Nanomedicine Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Molecular and Medical Research (MMR) Strategic Research Centre, Faculty of Health, Deakin University, Geelong, Victoria-3217, Australia
E-mail: jagat.kanwar@deakin.edu.au

c Departments of Ocular Oncology and Vitreoretina, Medical Research Foundation, Sankara Nethralaya, Chennai-600006, India

d L & T Ocular Pathology Department, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, India

Abstract

A chimeric aptamer–DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.

Graphical abstract: Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC00939A
Article type
Communication
Submitted
01 Feb 2015
Accepted
16 Feb 2015
First published
19 Mar 2015

Chem. Commun., 2015,51, 6940-6943

Author version available

Download author version (PDF)

Permissions

Request permissions

Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

N. Subramanian, J. R. Kanwar, B. Akilandeswari, R. K. Kanwar, V. Khetan and S. Krishnakumar, Chem. Commun., 2015, 51, 6940 DOI: 10.1039/C5CC00939A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements