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Issue 25, 2015
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One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

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Abstract

Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell proliferation inhibition in A549 cells.

Graphical abstract: One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

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Supplementary files

Article information


Submitted
22 Jan 2015
Accepted
02 Mar 2015
First published
02 Mar 2015

Chem. Commun., 2015,51, 5264-5267
Article type
Communication
Author version available

One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

A. Sousa-Herves, S. Wedepohl and M. Calderón, Chem. Commun., 2015, 51, 5264
DOI: 10.1039/C5CC00644A

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