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Issue 17, 2015
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Palladium-catalysed carbonylative α-arylation of nitromethane

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Abstract

A simple and mild Pd-catalysed carbonylative α-arylation of nitromethane has been realised providing access to α-nitro aryl ketones from an array of aryl and heteroaryl iodides. The methodology requires only a mild base and uses the convenient solid CO releasing molecule, COgen in a two-chamber system. Changing to the isotopically labelled 13COgen, [13C]-acyl labelling can be effected through the generation of a near stoichiometric amount of 13CO. Lastly, the significance of the generated products as synthetic intermediates is demonstrated.

Graphical abstract: Palladium-catalysed carbonylative α-arylation of nitromethane

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Article information


Submitted
07 Jan 2015
Accepted
22 Jan 2015
First published
23 Jan 2015

Chem. Commun., 2015,51, 3600-3603
Article type
Communication
Author version available

Palladium-catalysed carbonylative α-arylation of nitromethane

Z. Lian, S. D. Friis and T. Skrydstrup, Chem. Commun., 2015, 51, 3600
DOI: 10.1039/C5CC00123D

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