An intramolecular nucleosidation approach provides easy access to orotidine in high yields. Notably, orotate itself is used as a leaving group at the anomeric position. This method has the potential for facile access to derivatives of orotidine of therapeutic interest, with implications for prebiotic formation of nucleosides.
E.-K. Kim and R. Krishnamurthy, Chem. Commun., 2015, 51, 5618 DOI: 10.1039/C5CC00111K
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