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Issue 15, 2015
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Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

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Abstract

In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

Graphical abstract: Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

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Supplementary files

Article information


Submitted
06 Jan 2015
Accepted
09 Jan 2015
First published
15 Jan 2015

Chem. Commun., 2015,51, 3258-3261
Article type
Communication
Author version available

Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

I. Kviatkovski, L. Chernin, T. Yarnitzky, I. Frumin, N. Sobel and Y. Helman, Chem. Commun., 2015, 51, 3258
DOI: 10.1039/C4CC10393A

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