Issue 23, 2015
From the journal:

Chemical Communications

Copper catalysed amidation of aryl halides through chelation assistance†

Subban Kathiravan,a   Shishir Ghosh,b   Graeme Hogarthb  and  Ian A. Nicholls*ac  

* Corresponding authors

a Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Linnæus University, SE-391 82 Kalmar, Sweden
E-mail: ian.nicholls@lnu.se
Fax: +46 0480-446244

b Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK

c Department of Chemistry, BMC, Uppsala University, SE-751 23 Uppsala, Sweden

Abstract

A copper mediated C–N bond formation for the amidation of aryl halides using 8-aminoquinoline has been developed. This strategy provides efficient access to amides bearing two contiguous heterocyclic moieties and does not require the presence of additional ligands.

Graphical abstract: Copper catalysed amidation of aryl halides through chelation assistance

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Article information

DOI
https://doi.org/10.1039/C4CC09940K
Article type
Communication
Submitted
12 Dec 2014
Accepted
13 Feb 2015
First published
13 Feb 2015

Chem. Commun., 2015,51, 4834-4837

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Copper catalysed amidation of aryl halides through chelation assistance

S. Kathiravan, S. Ghosh, G. Hogarth and I. A. Nicholls, Chem. Commun., 2015, 51, 4834 DOI: 10.1039/C4CC09940K

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