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Issue 37, 2015
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Efficient co-delivery of a Pt(IV) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

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Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(IV) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Graphical abstract: Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

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Publication details

The article was received on 10 Dec 2014, accepted on 27 Mar 2015 and first published on 30 Mar 2015


Article type: Communication
DOI: 10.1039/C4CC09879J
Chem. Commun., 2015,51, 7859-7862

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    Efficient co-delivery of a Pt(IV) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

    R. Ma, Y. Wang, L. Yan, L. Ma, Z. Wang, H. C. Chan, S. Chiu, X. Chen and G. Zhu, Chem. Commun., 2015, 51, 7859
    DOI: 10.1039/C4CC09879J

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