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Issue 37, 2015
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Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

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Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(IV) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Graphical abstract: Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

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Supplementary files

Article information


Submitted
10 Dec 2014
Accepted
27 Mar 2015
First published
30 Mar 2015

Chem. Commun., 2015,51, 7859-7862
Article type
Communication

Efficient co-delivery of a Pt(IV) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

R. Ma, Y. Wang, L. Yan, L. Ma, Z. Wang, H. C. Chan, S. Chiu, X. Chen and G. Zhu, Chem. Commun., 2015, 51, 7859
DOI: 10.1039/C4CC09879J

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