Jump to main content
Jump to site search

Issue 20, 2015
Previous Article Next Article

Catalytic nucleic acids (DNAzymes) as functional units for logic gates and computing circuits: from basic principles to practical applications

Author affiliations

Abstract

This feature article addresses the implementation of catalytic nucleic acids as functional units for the construction of logic gates and computing circuits, and discusses the future applications of these systems. The assembly of computational modules composed of DNAzymes has led to the operation of a universal set of logic gates, to field programmable logic gates and computing circuits, to the development of multiplexers/demultiplexers, and to full-adder systems. Also, DNAzyme cascades operating as logic gates and computing circuits were demonstrated. DNAzyme logic systems find important practical applications. These include the use of DNAzyme-based systems for sensing and multiplexed analyses, for the development of controlled release and drug delivery systems, for regulating intracellular biosynthetic pathways, and for the programmed synthesis and operation of cascades.

Graphical abstract: Catalytic nucleic acids (DNAzymes) as functional units for logic gates and computing circuits: from basic principles to practical applications

Back to tab navigation

Publication details

The article was received on 10 Dec 2014, accepted on 03 Jan 2015 and first published on 22 Jan 2015


Article type: Feature Article
DOI: 10.1039/C4CC09874A
Author version
available:
Download author version (PDF)
Citation: Chem. Commun., 2015,51, 4144-4160
  •   Request permissions

    Catalytic nucleic acids (DNAzymes) as functional units for logic gates and computing circuits: from basic principles to practical applications

    R. Orbach, B. Willner and I. Willner, Chem. Commun., 2015, 51, 4144
    DOI: 10.1039/C4CC09874A

Search articles by author

Spotlight

Advertisements