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Issue 15, 2015
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Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity

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Abstract

The effects of the repeated number (RN) of aminoethylene (AE) units in polyaspartamide side chains were investigated for polyion complex (PIC)-based siRNA delivery. Reduction of the apparent RN from 3 to 2 by thiourea introduction increased a protonatable amine fraction in AE units at endosomal pH, leading to the efficient endosomal escape of siRNA-loaded PICs.

Graphical abstract: Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity

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Article information


Submitted
10 Dec 2014
Accepted
09 Jan 2015
First published
09 Jan 2015

Chem. Commun., 2015,51, 3158-3161
Article type
Communication
Author version available

Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity

H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata and K. Kataoka, Chem. Commun., 2015, 51, 3158
DOI: 10.1039/C4CC09859E

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