A Rh(NHC) phosphonate complex reacts with the lipases cutinase and Candida antarctica lipase B resulting in the first (soluble) artificial metalloenzymes formed by covalent active site-directed hybridization. When compared to unsupported complexes, these new robust hybrids show enhanced chemoselectivity in the (competitive) hydrogenation of olefins over ketones.
M. Basauri-Molina, C. F. Riemersma, M. A. Würdemann, H. Kleijn and R. J. M. Klein Gebbink, Chem. Commun., 2015, 51, 6792 DOI: 10.1039/C4CC09700A
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