Issue 12, 2015
From the journal:

Chemical Communications

Ultrasensitive detection of nucleic acids by template enhanced hybridization followed by rolling circle amplification and catalytic hairpin assembly†

Weiling Song,*a   Qiao Zhanga  and  Wenbo Suna  

* Corresponding authors

a Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: shenlan.2003@163.com
Fax: +86 532-84022700
Tel: +86 532-84022700

Abstract

An ultrasensitive protocol for fluorescent detection of DNA is designed by combining the template enhanced hybridization process (TEHP) with Rolling Circle Amplification (RCA) and Catalytic Hairpin Assembly (CHA), showing a remarkable amplification efficiency.

Graphical abstract: Ultrasensitive detection of nucleic acids by template enhanced hybridization followed by rolling circle amplification and catalytic hairpin assembly

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Article information

DOI
https://doi.org/10.1039/C4CC09453K
Article type
Communication
Submitted
26 Nov 2014
Accepted
20 Dec 2014
First published
22 Dec 2014

Chem. Commun., 2015,51, 2392-2395

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Ultrasensitive detection of nucleic acids by template enhanced hybridization followed by rolling circle amplification and catalytic hairpin assembly

W. Song, Q. Zhang and W. Sun, Chem. Commun., 2015, 51, 2392 DOI: 10.1039/C4CC09453K

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