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Issue 10, 2015
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C–H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes

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Abstract

The carbonylative coupling of aryl and heteroaryl bromides with polyfluoroarenes via palladium-catalyzed C–H activation is presented. This transformation proceeds efficiently at moderate reaction temperatures and does not require strong base or reactive intermediates. A near stoichiometric amount of CO is sufficient and the methodology can thus be easily expanded to include the preparation of [13C]-acyl labeled benzopolyfluorophenones.

Graphical abstract: C–H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes

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Supplementary files

Article information


Submitted
21 Nov 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

Chem. Commun., 2015,51, 1870-1873
Article type
Communication
Author version available

C–H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes

Z. Lian, S. D. Friis and T. Skrydstrup, Chem. Commun., 2015, 51, 1870
DOI: 10.1039/C4CC09303H

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