Issue 10, 2015

C–H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes

Abstract

The carbonylative coupling of aryl and heteroaryl bromides with polyfluoroarenes via palladium-catalyzed C–H activation is presented. This transformation proceeds efficiently at moderate reaction temperatures and does not require strong base or reactive intermediates. A near stoichiometric amount of CO is sufficient and the methodology can thus be easily expanded to include the preparation of [13C]-acyl labeled benzopolyfluorophenones.

Graphical abstract: C–H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes

Supplementary files

Article information

Article type
Communication
Submitted
21 Nov 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

Chem. Commun., 2015,51, 1870-1873

Author version available

C–H activation dependent Pd-catalyzed carbonylative coupling of (hetero)aryl bromides and polyfluoroarenes

Z. Lian, S. D. Friis and T. Skrydstrup, Chem. Commun., 2015, 51, 1870 DOI: 10.1039/C4CC09303H

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