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Issue 8, 2015

Nuclease-containing media for resettable operation of DNA logic gates

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Abstract

We designed and tested a system that allows DNA logic gates to respond multiple times to the addition of oligonucleotide inputs. After producing an output signal, the system spontaneously resets to the background state. This system does not require any operator action to achieve reset of a DNA logic gate, and may become useful for construction of reusable DNA-based computational devices.

Graphical abstract: Nuclease-containing media for resettable operation of DNA logic gates

Supplementary files

Article information


Submitted
20 Nov 2014
Accepted
03 Dec 2014
First published
03 Dec 2014

Chem. Commun., 2015,51, 1429-1431
Article type
Communication
Author version available

Nuclease-containing media for resettable operation of DNA logic gates

M. R. O'Steen, E. M. Cornett and D. M. Kolpashchikov, Chem. Commun., 2015, 51, 1429 DOI: 10.1039/C4CC09283J

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