Issue 19, 2015
From the journal:

Chemical Communications

Nuclease resistant oligonucleotides with cell penetrating properties†

Stefan Milton,a   Dmytro Honcharenko,a   Cristina S. J. Rocha,b   Pedro M. D. Moreno,‡b   C. I. Edvard Smithb  and  Roger Strömberg*a  

* Corresponding authors

a Karolinska Institutet, Department of Biosciences and Nutrition, Novum, Hälsovägen 7, SE-14183, Huddinge, Sweden
E-mail: Roger.Stromberg@ki.se

b Karolinska Institutet, Department of Laboratory Medicine, Novum, Hälsovägen 7, 14183, Huddinge, Sweden

Abstract

2′-O-AECM modified oligonucleotides provide an unusual combination of remarkable properties. This includes the combination of high resistance towards enzymatic degradation and the spontaneous cellular uptake of AECM oligonucleotides.

Graphical abstract: Nuclease resistant oligonucleotides with cell penetrating properties

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Article information

DOI
https://doi.org/10.1039/C4CC08837A
Article type
Communication
Submitted
05 Nov 2014
Accepted
28 Jan 2015
First published
29 Jan 2015

Chem. Commun., 2015,51, 4044-4047

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Nuclease resistant oligonucleotides with cell penetrating properties

S. Milton, D. Honcharenko, C. S. J. Rocha, P. M. D. Moreno, C. I. Edvard Smith and R. Strömberg, Chem. Commun., 2015, 51, 4044 DOI: 10.1039/C4CC08837A

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