Issue 14, 2015
From the journal:

Chemical Communications

Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry†

F. Cagide,‡a   T. Silva,‡a   J. Reis,a   A. Gaspar,a   F. Borges,*a   L. R. Gomesb  and  J. N. Lowc  

* Corresponding authors

a CIQUP/Departamento de Química e Bioquímica Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal
E-mail: fborges@fc.up.pt

b REQUIMTE/FP-ENAS-Faculdade de Ciências de Saúde, Escola Superior de Saúde da UFP, Universidade Fernando Pessoa, P-4200-150 Porto, Portugal

c Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen, Scotland

Abstract

The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.

Graphical abstract: Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

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Article information

DOI
https://doi.org/10.1039/C4CC08798D
Article type
Communication
Submitted
09 Nov 2014
Accepted
24 Dec 2014
First published
24 Dec 2014

Chem. Commun., 2015,51, 2832-2835

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Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

F. Cagide, T. Silva, J. Reis, A. Gaspar, F. Borges, L. R. Gomes and J. N. Low, Chem. Commun., 2015, 51, 2832 DOI: 10.1039/C4CC08798D

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