Issue 8, 2015
From the journal:

Chemical Communications

A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer†

Haiwei Ji,a   Yijia Guan,a   Li Wu,a   Jinsong Ren,a   Daisuke Miyoshi,b   Naoki Sugimotob  and  Xiaogang Qu*a  

* Corresponding authors

a Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China
E-mail: xqu@ciac.ac.cn

b FIBER, Konan University, Kobe, Japan

Abstract

Cyclin A2 is a promising cancer prognostic indicator, but its intracellular in situ imaging is still a challenging task. This work designs an “off–on” fluorescent probe, which can fluorescently detect intracellular cyclin A2 and distinguish cancer cells. In addition, this work sheds light on the development of future protein biosensors.

Graphical abstract: A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer

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Article information

DOI
https://doi.org/10.1039/C4CC08789E
Article type
Communication
Submitted
04 Nov 2014
Accepted
28 Nov 2014
First published
28 Nov 2014

Chem. Commun., 2015,51, 1479-1482

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A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer

H. Ji, Y. Guan, L. Wu, J. Ren, D. Miyoshi, N. Sugimoto and X. Qu, Chem. Commun., 2015, 51, 1479 DOI: 10.1039/C4CC08789E

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