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Issue 25, 2015
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Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

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Abstract

Influenza viruses bind to mucosal glycans to gain entry into a host organism and initiate infection. The target glycans are often displayed in multivalent arrangements on proteins; however, how glycan presentation influences viral specificity is poorly understood. Here, we report a microarray platform approximating native glycan display to facilitate such studies.

Graphical abstract: Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

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Article information


Submitted
31 Oct 2014
Accepted
31 Dec 2014
First published
31 Dec 2014

Chem. Commun., 2015,51, 5326-5329
Article type
Communication
Author version available

Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

M. L. Huang, M. Cohen, C. J. Fisher, R. T. Schooley, P. Gagneux and K. Godula, Chem. Commun., 2015, 51, 5326
DOI: 10.1039/C4CC08613A

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