Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
W. Chen, G. Luo, Q. Lei, H. Jia, S. Hong, Q. Wang, R. Zhuo and X. Zhang, Chem. Commun., 2015, 51, 465 DOI: 10.1039/C4CC07563C
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