A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse†
Abstract
A very fast-responsive fluorescent probe PZ–Py for imaging mitochondrial HClO/ClO−, with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ–Py was successfully applied in the imaging of endogenous HClO/ClO− in the mitochondria of RAW 264.7 cells and living nude mouse.