Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

Ryo Nishihara; Hideyuki Suzuki; Emi Hoshino; Sakura Suganuma; Moritoshi Sato; Tsuyoshi Saitoh; Shigeru Nishiyama; Naoko Iwasawa; Daniel Citterio; Koji Suzuki

doi:10.1039/C4CC06886F

Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution†

Ryo Nishihara,^a Hideyuki Suzuki,^b Emi Hoshino,^a Sakura Suganuma,^b Moritoshi Sato,^b Tsuyoshi Saitoh,^c Shigeru Nishiyama,^c Naoko Iwasawa,^a Daniel Citterio^a and Koji Suzuki*^a

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^a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
E-mail: suzuki@applc.keio.ac.jp

^b Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan

^c Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan

Abstract

Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to hitherto reported compounds.

Chemical Communications

Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution†

Abstract

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Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

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