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Issue 4, 2015
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Density gradients at hydrogel interfaces for enhanced cell penetration

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Abstract

We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.

Graphical abstract: Density gradients at hydrogel interfaces for enhanced cell penetration

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Supplementary files

Article information


Submitted
02 Dec 2014
Accepted
26 Dec 2014
First published
14 Jan 2015

Biomater. Sci., 2015,3, 586-591
Article type
Communication

Density gradients at hydrogel interfaces for enhanced cell penetration

B. R. Simona, L. Hirt, L. Demkó, T. Zambelli, J. Vörös, M. Ehrbar and V. Milleret, Biomater. Sci., 2015, 3, 586
DOI: 10.1039/C4BM00416G

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