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Issue 4, 2015
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Density gradients at hydrogel interfaces for enhanced cell penetration

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Abstract

We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.

Graphical abstract: Density gradients at hydrogel interfaces for enhanced cell penetration

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Publication details

The article was received on 02 Dec 2014, accepted on 26 Dec 2014 and first published on 14 Jan 2015


Article type: Communication
DOI: 10.1039/C4BM00416G
Citation: Biomater. Sci., 2015,3, 586-591
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    Density gradients at hydrogel interfaces for enhanced cell penetration

    B. R. Simona, L. Hirt, L. Demkó, T. Zambelli, J. Vörös, M. Ehrbar and V. Milleret, Biomater. Sci., 2015, 3, 586
    DOI: 10.1039/C4BM00416G

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