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Issue 20, 2015
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Single-cell analysis based on lab on a chip fluidic system

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Abstract

The combination of nano/microfabrication-based technologies with cell biology has laid the foundation for facilitating the spatiotemporal analysis of single cells under well-defined physiologically relevant conditions. This combined technology allows so far unachievable insights into simultaneous characterization and manipulation of cells. Nano/microfluidic technology provides cost-effective, integrated, and high-throughput systems that are promising substitutes for conventional biological laboratory methods going from fundamental research to point-of-care diagnosis. This inscription reviews the latest progress regarding cell manipulation methods based on dielectrophoresis, electrophoresis, optical, acoustic, encaging, hydrodynamic, magnetite, centrifugal cell trapping/sorting, and cell characterization based on mechanical, electrical, biochemical, and optical methods using fluidic systems.

Graphical abstract: Single-cell analysis based on lab on a chip fluidic system

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Article information


Submitted
02 Aug 2015
Accepted
09 Aug 2015
First published
12 Aug 2015

Anal. Methods, 2015,7, 8524-8533
Article type
Minireview

Single-cell analysis based on lab on a chip fluidic system

A. Valizadeh and A. Y. Khosroushahi, Anal. Methods, 2015, 7, 8524
DOI: 10.1039/C5AY02029H

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