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Issue 18, 2015

A simple and dual functional dynamic light scattering (DLS) probe for rapid detection of mercury ions and biothiols

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Abstract

Mercury (Hg2+) is a toxic heavy metal and commonly exists in the ecological environment and polluted biological samples. Small-molecular-weight biological thiols (biothiols, such as GSH and Cys) play an essential role in many biological events. Till now, recently developed approaches for monitoring Hg2+ and biothiols commonly require large and cumbersome instruments, complicated procedures, or an elegant design and synthesis. In this study, we have developed a dynamic light scattering (DLS) based technique for the dual detection of Hg2+ and biothiols. This label free assay based on DNA-mediated gold nanoparticles (DNA–AuNPs) could present an effective toolkit for the determination of Hg2+ (or biothiol) containing samples within 30 min without complicated procedures. To best of our knowledge, this is the first DLS based probe for the dual detection of Hg2+ and biothiols. It exhibited potential for high throughput screening of Hg2+ (or biothiol) containing samples.

Graphical abstract: A simple and dual functional dynamic light scattering (DLS) probe for rapid detection of mercury ions and biothiols

Article information


Submitted
19 Jul 2015
Accepted
03 Aug 2015
First published
07 Aug 2015

Anal. Methods, 2015,7, 7455-7460
Article type
Paper

A simple and dual functional dynamic light scattering (DLS) probe for rapid detection of mercury ions and biothiols

C. Fu, H. Ma, C. Huang and N. jia, Anal. Methods, 2015, 7, 7455 DOI: 10.1039/C5AY01880C

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