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Issue 20, 2015
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Gd–XO: a colourimetric probe for the complexation of Gd3+ with DO3A-type ligands

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Abstract

Small molecule Gd-based MRI contrast agents possess both thermodynamic stability and kinetic inertness, and have been used safely in the clinic. Since the kinetics of Gd3+-complex formation with macrocyclic ligands is slow, convenient methods to investigate their rates of formation are desirable. To this end, heptadentate macrocyclic ligands 1 and 2 were synthesized, and their binding with Gd3+ was investigated using the Gd3+–Xylenol Orange (Gd–XO) complex as a colourimetric probe. A significantly faster rate of complex formation was observed with 1 in comparison with 2, demonstrating that the hydrophobic functionality of 2 plays a role in reducing the rate of complex formation of the ligand with Gd3+. Other macrocyclic ligands can be conveniently assessed for their binding and kinetic properties using the methods described.

Graphical abstract: Gd–XO: a colourimetric probe for the complexation of Gd3+ with DO3A-type ligands

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Supplementary files

Article information


Submitted
05 Jul 2015
Accepted
30 Aug 2015
First published
01 Sep 2015

Anal. Methods, 2015,7, 8967-8969
Article type
Technical Note
Author version available

Gd–XO: a colourimetric probe for the complexation of Gd3+ with DO3A-type ligands

K. F. G. Suazo and A. J. L. Villaraza, Anal. Methods, 2015, 7, 8967
DOI: 10.1039/C5AY01738F

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