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Issue 17, 2015
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Supermacroporous polyHIPE and cryogel monolithic materials as stationary phases in separation science: a review

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Abstract

With their unique supermacroporous architecture, polyHIPEs (high internal phase emulsions) and cryogels have huge potential as analytical separation stationary phases. Due to their fully interconnected pore structure, mass transfer occurs predominantly via convection, potentially allowing for enhanced chromatographic performance. Additionally their surface functionalities can be tailored by modification of substrates both during and post fabrication. Their surface area is typically lower than comparable particulate stationary phases and problems with their rigidity persist. For these reasons, apart from their applications for large biomolecule analysis, the potential of cryogel and polyHIPE materials as separation phases in separation science have not been extensively realised. However, multiple strategies exist to overcome these limitations, potentially enabling the application of cryogels and polyHIPEs for a diverse range of separations. Current applications, such as chelation resins, which demonstrate the diverse interaction modes of both supermacroporous substrates, and applications of both substrates in analytical separations are considered in this review. Additionally the limitations of these technologies are explored, and strategies to overcome these limitations and further develop these monolithic phases for analytical separations are presented.

Graphical abstract: Supermacroporous polyHIPE and cryogel monolithic materials as stationary phases in separation science: a review

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Article information


Submitted
08 May 2015
Accepted
31 May 2015
First published
10 Jun 2015

Anal. Methods, 2015,7, 6967-6982
Article type
Critical Review

Supermacroporous polyHIPE and cryogel monolithic materials as stationary phases in separation science: a review

S. Choudhury, D. Connolly and B. White, Anal. Methods, 2015, 7, 6967
DOI: 10.1039/C5AY01193K

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